Leptomeningeal Metastases (LM) is sometimes referred to as leptomeningeal cancer,
leptomeningeal disease, neoplastic meningitis, or meningeal carcinomatosis. This rare
but serious condition happens when cancer cells spread to the membranes surrounding
the brain and spinal cord.  Leptomeningeal Metastases is most commonly found in
patients with melanoma, breast, lung, or gastrointestinal cancer. Unfortunately, there are
no FDA approved treatments specifically for Leptomeningeal Metastases.


Plus Therapeutics is developing a new targeted radiation therapy, Rhenium (186Re)
Obisbemeda, for central nervous system cancers such as Leptomeningeal Metastases.
 In the U.S. ReSPECT-LM clinical trial, doctors will give Leptomeningeal Metastases
patients a single dose of Rhenium (186Re) Obisbemeda through a small catheter
placed under the patient’s scalp. This drug will be administered in less than 5 minutes in
a hospital setting and the patient will go home the same day.


For more information about the ReSPECT-LM Clinical Trial, please visit respect-
trials.com/lm. (NCT05034497). 

ReSPECT-LM Patient Story | Marlyn, Leptomeningeal Metastases Survivor 


At just 31 years old, while engaged in her Medical Residency in Pediatrics, Dr. Marlyn
Cabrera faced a life-altering challenge: a diagnosis of breast cancer. For the next two
decades, she navigated the complex landscape of treatment and recovery, showing
incredible strength and determination. However, her journey took another difficult turn
when the cancer metastasized to her cerebral spinal fluid (CSF), and she was
diagnosed with leptomeningeal metastases and given an estimated life expectancy of
just 2 to 4 months. 

Today, more than six years after her initial diagnosis, Marlyn stands as a beacon of
hope and resilience. After participating in the ReSPECT-LM Clinical Trial, she is eager
to share her journey and the lessons learned along the way. Her firsthand experience
emphasizes the importance of maintaining a positive mindset and the transformative
power of hope, bolstered by the unwavering support of her dedicated healthcare team
and loved ones.